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Zap before the shot: cold plasma eases dental needle pain

NCT ID NCT07288125

Symptom relief Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested if applying cold atmospheric plasma to the gums for one minute before a dental numbing shot reduces pain. Thirty healthy adults received the plasma on one side of the mouth and a standard injection on the other. The goal was to see if the plasma made the injection more comfortable and improved patient satisfaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Sep 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between 18 and 40 years of age; * American Society of Anesthesiologists (ASA) physical status classification I (systemically healthy); * No known allergy or intolerance to local anesthetic agents or cold atmospheric plasma (CAP); * Presence of similar bilateral dental treatment indications in the maxilla or mandible. Exclusion Criteria: * Pregnancy or breastfeeding; * Presence of active lesions, ulceration, or signs of infection in the mucosa at the injection site; * Immunodeficiency or systemic immunosuppressive therapy; * Use of anticoagulant medications; * Previous exposure to CAP therapy for any purpose; * History of allergy to local anesthetic agents; * Presence of neurological or psychiatric disorders that may affect pain perception.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cold atmospheric plasma Dental anesthesia

Contacts and locations

Locations

  • Kahramanmaras Sutcu Imam University, Faculty of Dentistry

    Kahramanmaraş, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.