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Real-World data on HAE drug lanadelumab: does it cut attacks?

NCT ID NCT05469789

Knowledge-focused Sponsor: Takeda Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study follows 50 people in the UK with hereditary angioedema (HAE) types I or II who are taking lanadelumab. Researchers will compare the number of HAE attacks in the year before starting the drug to up to two years after. The goal is to see how well the drug works outside of clinical trials, using patient diaries and medical records.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lanadelumab
What this could lead to
If successful, this study could confirm that lanadelumab reduces HAE attacks in everyday clinical practice, supporting its use as a standard treatment.
What could go wrong
This is an observational study with only 50 participants, so results may not apply to all patients. It does not test a new drug or prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The population of this survey is all participants with HAE type I or II treated with lanadelumab in hospitals within the UK.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion: * Documented diagnosis of HAE type I or II (confirmed through laboratory testing) * Documented initiation of treatment with lanadelumab or due to be initiated within next 4 weeks * Greater than or equal to (≥)12 years of age at initiation of treatment with lanadelumab * ≥12 months of continuous medical record data before initiation of treatment with lanadelumab Exclusion: • Exposure to lanadelumab administered as an investigation product in a clinical trial setting at any point in time

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Conditions

The condition(s) this trial relates to.

hereditary angioedema hereditary angioedema type 1 hereditary angioedema type 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hereditary angioedema (HAE)

Contacts and locations

Locations

  • Barts Health NHS Trust

    London, England, E1 1BB, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.