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Lactate: a surprising booster for failing hearts?

NCT ID NCT06121323

Knowledge-focused Sponsor: Henrik Wiggers Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how lactate, a natural substance made by the body, affects heart function in 12 people with chronic heart failure. Researchers gave lactate as an infusion and as a drink, then measured changes in blood flow and heart pressure. The goal was to understand if lactate could help the heart work better, but this was a small, early study to gather information, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sodium lactate
What this could lead to
If it works, this could point toward new ways to manage heart failure by using lactate to improve heart function.
What could go wrong
This is a very small, early-stage study with only 12 participants, so results may not apply to everyone. It is designed to understand basic effects, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Nov 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic heart failure * NYHA II-III * Left ventricular ejection fraction \<40% * Negative urine-HCG for women with childbearing potential Exclusion Criteria: * Diabetes or HbA1c \>48 mmol/mol * Significant cardiac valve disease * Severe stable angina pectoris * Severe comorbidity as judged by the investigator * Inability to give informed consent * Age \<18 years * Other disease or treatment making subject unsuitable for study participation as judged by the investigator.

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Conditions

The condition(s) this trial relates to.

systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure, systolic

Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, Central Jutland, 8200, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.