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Simple supplement may shield First-Time moms from dangerous pregnancy hypertension

NCT ID NCT04979793

Prevention Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether taking L-citrulline, a natural amino acid supplement, daily from early pregnancy can prevent high blood pressure conditions like preeclampsia in women expecting their first child. About 338 healthy first-time mothers between 12-16 weeks pregnant will receive either the supplement or a placebo. The trial is currently on hold, so results are pending.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
L-citrulline
What this could lead to
If it works, this could point toward a simple supplement to prevent pregnancy-related high blood pressure in first-time mothers.
What could go wrong
This is a very early Phase 1 trial, currently suspended, so results are far from certain. The supplement may not reduce blood pressure or may cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 338 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Nulliparous (no previous pregnancy greater than 20 weeks) * Gestational age of pregnancy between 12 and 16 weeks Exclusion Criteria: * Known fetal anomaly or chromosomal abnormality * Early fetal growth restriction * Fetal demise or planned termination * Participation in another study that may influence this study * Known maternal kidney disease * Known maternal electrolyte imbalance * Known allergies to study interventions * Preexisting hypertension (chronic hypertension) * Known gastric ulcer * Incarcerated status * Planned delivery at non-UTMB hospital * Known lactose intolerance

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Conditions

The condition(s) this trial relates to.

eclampsia preeclampsia hypertension, pregnancy-induced prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gestational hypertension Preeclampsia and eclampsia Pregnancy induced hypertension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Texas Medical Branch

    Galveston, Texas, 77555-0156, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.