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Can krill oil ease chronic pain in seniors?

NCT ID NCT06580912

Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether taking krill oil daily for 12 weeks helps older adults with chronic musculoskeletal pain. Forty participants aged 60 and older took either krill oil or a vegetable oil placebo. The main goal was to see if a larger trial is possible, focusing on adherence and acceptability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
krill oil
What this could lead to
If it works, this could point toward a simple nutritional supplement to help older adults manage chronic pain and stay mobile.
What could go wrong
This is a small pilot study (40 people) focused on feasibility, not proof of effectiveness. Results may not apply to everyone, and krill oil may not reduce pain better than other oils.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

40 people

The number who actually took part.

Started

Jan 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Able to provide informed consent * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, aged ≥60 years * Exhibiting chronic musculoskeletal pain of the hip, knees, or lower back (\>3 months) * Average pain ≥4 on a 0-10 numeric rating scale * Exhibiting moderate mobility limitations (Short Physical Performance Battery score 4-10) * Ability to take oral supplements and be willing to adhere to the supplementation regimen * Agreement to adhere to Lifestyle Considerations throughout study duration Exclusion Criteria: * Any known coagulation or bleeding disorders * Standing regimen of anticoagulants or full-dose aspirin * Regular use of opioids or high-dose NSAIDs * Taking medication known to affect muscle (e.g. steroids) * Taking selective serotonin reuptake inhibitors (SSRIs) * Omega-3 supplementation within the past 3 months * High consumption of fatty fish (\>2 servings/week) * Habitual supplementation with other complementary medicines/supplements that may affect the study results, including St. John's Wort * Known allergy to seafood * Clinically significant conditions: diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (\>150/90mmhg at baseline), cancer or cancer that has been in remission \>5 years * History of atrial fibrillation or atrial flutter * Dementia * History of smoking, alcohol abuse, or illicit drug use * Ambulatory impairments which would limit the ability to perform physical function tests * Treatment with another investigational drug or other intervention within 3 months * Planning a surgical procedure during the study period * Planning to permanently leave the area during the study period

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Conditions

The condition(s) this trial relates to.

Chronic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic musculoskeletal pain

Contacts and locations

Locations

  • UF Claude D. Pepper Older Americans Independence Center

    Gainesville, Florida, 32610, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.