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New study aims to cut opioid use after knee replacement with targeted nerve blocks

NCT ID NCT07677215

Symptom relief Sponsor: Poznan University of Medical Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial compares three ways to manage pain after total knee replacement. All patients receive standard nerve blocks, but some also get an anti-inflammatory drug (dexamethasone) or a combination of dexamethasone and a sedative (dexmedetomidine). The goal is to see which approach reduces the need for opioids and improves recovery. The study involves 120 adults aged 60 to 100 undergoing knee replacement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ropivacaine, dexamethasone, dexmedetomidine
What this could lead to
If successful, this could identify a safer, more effective pain management approach for knee replacement patients, reducing opioid dependence and speeding recovery.
What could go wrong
This is a single-center trial with 120 participants, so results may not apply broadly. Adding drugs like dexmedetomidine may increase side effects such as low blood pressure or sedation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 60 and 100 years * Scheduled for elective primary unilateral total knee arthroplasty * American Society of Anesthesiologists (ASA) physical status I-III * Ability to understand study procedures and provide written informed consent * Eligibility for spinal anesthesia and ultrasound-guided regional anesthesia according to institutional standards Exclusion Criteria: * Known allergy or hypersensitivity to ropivacaine, dexamethasone, dexmedetomidine, or any study-related medication * Contraindications to spinal anesthesia or peripheral nerve blocks * Coagulation disorders or anticoagulant therapy preventing safe regional anesthesia * Infection at the planned puncture site or systemic infection * Severe neurological disorders affecting lower limb sensory or motor function * Severe hepatic, renal, or uncontrolled cardiovascular disease * Clinically significant bradycardia or advanced atrioventricular conduction abnormalities * Chronic opioid use for more than 3 months before surgery * Uncontrolled diabetes mellitus or contraindications to dexamethasone administration * Inability or refusal to provide written informed consent

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Poznan University of Medical Sciences

    Poznan, 62-701, Poland

  • The John Paul II Catholic University of Lublin

    Lublin, Poland

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