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Knee surgery pain relief showdown: which nerve block combo wins?
NCT ID NCT07324486
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will compare two different nerve block combinations used alongside standard anesthesia for total knee replacement surgery. One group gets an adductor canal block plus an iPACK block, while the other gets an adductor canal block plus a genicular nerve block. The goal is to see which combination provides better pain relief and helps patients regain function faster. The trial plans to enroll 50 adults and has not yet started recruiting.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- nerve blocks (adductor canal block, iPACK block, genicular nerve block) with local anesthetic (bupivacaine)
- What this could lead to
- If one nerve block combination works better, it could mean less pain and faster recovery after knee replacement surgery.
- What could go wrong
- This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. The study hasn't started yet, and there is always a chance neither method proves clearly better.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Feb 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients scheduled for spinal anesthesia with TDA. 2. Age ≥18. 3. American Society of Anesthesiologists (ASA) physical status score I-III. 4. Patients capable of providing informed consent. Exclusion Criteria: 1. Active infection at the injection site. 2. Coagulopathy or systemic sepsis. 3. Severe hypovolemia. 4. Patients who refuse regional anesthesia. 5. Known allergy to local anesthetics. 6. Cognitive impairment or uncooperative patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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