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Knee surgery pain relief showdown: which nerve block combo wins?

NCT ID NCT07324486

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will compare two different nerve block combinations used alongside standard anesthesia for total knee replacement surgery. One group gets an adductor canal block plus an iPACK block, while the other gets an adductor canal block plus a genicular nerve block. The goal is to see which combination provides better pain relief and helps patients regain function faster. The trial plans to enroll 50 adults and has not yet started recruiting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve blocks (adductor canal block, iPACK block, genicular nerve block) with local anesthetic (bupivacaine)
What this could lead to
If one nerve block combination works better, it could mean less pain and faster recovery after knee replacement surgery.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. The study hasn't started yet, and there is always a chance neither method proves clearly better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients scheduled for spinal anesthesia with TDA. 2. Age ≥18. 3. American Society of Anesthesiologists (ASA) physical status score I-III. 4. Patients capable of providing informed consent. Exclusion Criteria: 1. Active infection at the injection site. 2. Coagulopathy or systemic sepsis. 3. Severe hypovolemia. 4. Patients who refuse regional anesthesia. 5. Known allergy to local anesthetics. 6. Cognitive impairment or uncooperative patients.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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