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Can a brain monitor guide safer anesthesia during knee replacement?

NCT ID NCT07736352

Knowledge-focused Sponsor: China-Japan Friendship Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether adding midazolam, dexmedetomidine, or esketamine to standard propofol anesthesia helps maintain the right depth of unconsciousness during knee replacement. One hundred adults scheduled for surgery will have their brain waves and vital signs monitored as the anesthesia dose is gradually lowered. The goal is to identify the ideal brain-monitor readings and drug levels that keep patients safely asleep without over-sedation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol, remifentanil, midazolam, dexmedetomidine, esketamine
What this could lead to
If successful, this could help anesthesiologists tailor drug combinations for safer, more precise anesthesia during knee replacement surgery.
What could go wrong
This is a small, early-phase trial focused on monitoring rather than outcomes, so results may not change practice directly. Individual responses to anesthesia vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 years * American Society of Anesthesiologists (ASA) physical status I or II * Body Mass Index (BMI) 18 to 30 kg/m² * Scheduled for elective unilateral total knee replacement surgery * Willing to participate in the study and signed informed consent form, and able to comply with the intervention and assessment procedures Exclusion Criteria: * History of neurological disorders * Cognitive dysfunction assessed by the Mini-Cog scale * History of antipsychotic or sedative medication use in the past 4 weeks * Poorly controlled or untreated hypertension * Sinus bradycardia, cardiac conduction block, or severe heart failure * Acute angle-closure glaucoma * Allergic to intravenous anesthetics * Hearing impairment, could not cooperate in intervention and evaluation * Contraindications to tourniquet use on the upper arm

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asa class I/II patients Elective surgical patients Knee osteoarthritis Replacement, knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.