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Can an Anti-Gravity treadmill or supplements beat knee arthritis pain?

NCT ID NCT07399743

Symptom relief Sponsor: Badr University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two add-on treatments for knee osteoarthritis in overweight women: walking on an anti-gravity treadmill that unloads the joints, or taking alpha-lipoic acid and omega-3 supplements. Both aim to reduce pain and improve function better than standard physical therapy alone. The trial will enroll 160 women aged 20-45 with mild to moderate knee osteoarthritis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Alpha-lipoic acid and omega-3 fatty acids
What this could lead to
If successful, this could point to a more effective combination of treatments to reduce pain and improve mobility in overweight women with knee osteoarthritis.
What could go wrong
This is a Phase 3 trial, but it has not yet started recruiting. The results may not apply to all people with knee osteoarthritis, and the supplements or therapy may not provide significant benefits over standard physical therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion criteria 1. Female participants aged between 20-45 years. 2. Their BMI ranged between 20-25 kg/m². 3. All had radiographic confirmation of mild to moderate knee osteoarthritis. 4. Medical history recorded with no major prior injuries or surgeries affecting outcomes. 5. Participants reported knee pain, functional limitation, and activity-related symptoms. 6. Radiographic grading confirmed as Kellgren-Lawrence grade II or III. Exclusion criteria: 1. No recent traumatic hip, knee, or ankle surgery within the past 6 months. 2. No severe knee OA (Kellgren-Lawrence grade 0 or 4). 3. No history of rheumatoid arthritis, chronic reactive arthritis, or psoriatic arthritis. 4. Free from conditions that limit safe study participation or adherence to protocol. 5. No neurological impairments affecting lower limb function. 6. No contraindications to exercise or physiotherapy (e.g., severe cardiovascular, respiratory, or metabolic conditions). 7. Not pregnant or planning pregnancy during the study. 8. Not involved in other clinical trials or conflicting interventions (e.g., intra-articular injections, surgery, or rehab programs).

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.