Could blocking tiny leg arteries relieve knee arthritis pain?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 40 - 70 years of age. * Unilaterally dominant symptomatic OA (bilateral radiographic OA will not exclude). * Symptomatically refractory of at least 3 months of medical and/or rehabilitation measures (anti-inflammatory drugs, and/or physical therapy, and/or strength conditioning, and/or intra-articular injections of the affected knee in the last 3 months). * Kellgren-Lawrence grade 1, 2, or 3 on radiograph of the knee * Willing to comply with the protocol requirements and willing to undergo non- contrast MRI during screening and at 12 months. * Willing to comply with regular follow up during the 12 month follow-up period. * Not a current candidate for partial or total knee arthroplasty. * WOMAC Score \>=6 in at least 2 categories. Exclusion Criteria: * BMI \>35 kg/m2 * Advanced peripheral arterial disease (resting ABI \<= 0.9). * Known significant peripheral arterial disease precluding common femoral catheterization * Have smoked tobacco regularly (smoking 1 or more tobacco product(s) per week) within the last year * Diabetics with hemoglobin A1C of \>9% * Previous lower extremity embolization * Uncontrolled emotional disorders per patient medical history * Chronic pain syndrome or currently under a pain contract. * Anatomic variants involving the lower extremities which would increase the risk of non-target embolization * Renal insufficiency based on an estimated GFR\<45 ml/min who are not already on hemodialysis. * Abnormal INR (\>1.5) * Platelet count \<50x109/L. * Currently receiving medications for anticoagulation which cannot safely be held for the procedure and for 7 days post-procedure. * Known severe allergy to iodine which cannot be adequately pre-medicated * Pregnant or intend to become pregnant within 6 months of the procedure * Contraindication to drugs used for moderate sedation during interventional procedures, including Midazolam and Fentanyl * Life expectancy \<60 months * Currently enrolled or who plan to enroll in other investigations that conflict with follow-up testing or confounds data in this trial * Contraindications to medical and physical rehabilitative treatments of OA. * Advanced atherosclerosis. * Current or previous lower extremity fistula. * Rheumatoid arthritis or seronegative arthropathies. * WOMAC Pain Scale \< 6 * Steroid injection in the affected joint within 3 months of screening. I- n investigator assessment, patient is not a candidate for study participation