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Mismatched kidney transplants boost survival in seniors

NCT ID NCT07436338

Disease control Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 1,819 elderly patients (aged 60+) with end-stage kidney disease to see if getting a living donor kidney transplant that is not a perfect match (ABO- or HLA-incompatible) helps them live longer compared to waiting for a compatible deceased donor. The approach uses desensitization therapy to reduce the risk of rejection. Results suggest that earlier transplantation with a mismatched kidney may improve survival for older patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,819 people

The number who actually took part.

Started

Oct 2010

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study population was derived from elderly patients registered on the kidney transplant waiting lists at two tertiary referral transplant centers in South Korea (Severance Hospital and Seoul National University Hospital). Participants were identified from institutional transplant databases, and deidentified clinical data were retrospectively collected and analyzed.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 60 years or older * Diagnosis of end-stage kidney disease (ESKD) requiring maintenance dialysis * Registered on the kidney transplant waiting list between November 2010 and December 2023 Exclusion Criteria: * Complement-dependent cytotoxicity crossmatch positive

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

End stage kidney disease (ESRD) Kidney transplant

Contacts and locations

Locations

  • Seoul National University College of Medicine

    Seoul, Jongno-gu, 03080, South Korea

  • Yonsei University College of Medicine

    Seoul, Seodaemun-gu, 03722, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.