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Should you remove kidney stones to stop UTIs? study seeks answers

NCT ID NCT04495699

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 94 adults who have both recurrent urinary tract infections and kidney stones that are not blocking the kidney. Researchers wanted to see if surgically removing these stones reduces the number of future UTIs compared to just monitoring them. Patients chose with their doctor whether to have stone removal or not, and the team tracked infections for a year. The goal is to provide better guidance for treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors decide whether to remove silent kidney stones to prevent repeat UTIs.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

94 people

The number who actually took part.

Started

Sep 2020

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with recurrent UTIs and asymptomatic renal calculi.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (all of the following): * recurrent UTIs, defined as 3 positive urine cultures of specific organisms with symptoms within 12 months (or 2 positive cultures with symptoms within 6 months) prior to clinical assessment * non-obstructing renal stone(s) on imaging within 6 months of initial visit Exclusion Criteria: * age \< 18 years * pregnancy * hydronephrosis or evidence of obstruction * presence of a foreign body in urinary tract (e.g. Foley, ureteral stent, nephrostomy tube) at the time of UTI diagnosis * concurrent bladder calculi * Urinary diversion or previous surgery involving segments of bowel interposed into the urinary tract (ileal conduit, ileal ureter etc.)

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis urinary tract infection urinary tract infections, recurrent, susceptibility to urolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney stone Urinary tract infections

Contacts and locations

Locations

  • Columbia University

    New York, New York, 10027, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Arizona

    Phoenix, Arizona, 85054, United States

  • University of California San Diego

    San Diego, California, 92093, United States

  • Vancouver General Hospital/University of British Columbia

    Vancouver, British Columbia, V6T1Z4, Canada

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

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