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Timing of shock wave therapy may spare kidneys from hidden harm

NCT ID NCT07341269

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study involved 50 adults with kidney stones who received shock wave therapy (ESWL) to break up stones. Researchers wanted to see if waiting longer between treatment sessions caused less kidney damage. They measured two proteins in urine (NGAL and KIM-1) that signal kidney injury. The goal was to find the safest time gap between sessions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

50 people

The number who actually took part.

Started

Jun 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients aged 18 years and older with urinary system stone disease who are undergoing extracorporeal shock wave lithotripsy (SWL) as part of routine clinical care. Participants are prospectively observed to evaluate changes in urinary NGAL and KIM-1 levels as biomarkers of renal injury associated with SWL. Patients with active urinary tract infection, suspected struvite stones, urinary diversion, nephrostomy tube, bleeding disorders, pregnancy, anticoagulant use, or cardiac arrhythmia are excluded.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years and older * Patients with an indication for extracorporeal shock wave lithotripsy (SWL) for urinary system stone disease Exclusion Criteria: * Positive nitrite on urinalysis prior to SWL * Positive urine culture prior to SWL, defined as \>10⁵ CFU/mL bacterial growth * Suspected struvite stone, based on previous or partial stone analysis * Presence of a nephrostomy tube * Presence of urinary diversion * History of bleeding disorders * Pregnancy * Use of anticoagulant therapy * History of cardiac arrhythmia

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Conditions

The condition(s) this trial relates to.

Urinary Calculi urolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Renal injury Urinary stone

Contacts and locations

Locations

  • Marmara University School of Medicine Urology Department

    Istanbul, Istanbul, 34854, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.