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Ketone drink study reveals surprising effects on blood hormones

NCT ID NCT06053138

Knowledge-focused Sponsor: Central Jutland Regional Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study with 16 healthy adults tested how a ketone supplement affects beta-hydroxybutyrate (BHB) levels and erythropoietin (EPO), a hormone that controls red blood cell production. Participants took either the ketone drink or a placebo for two weeks. Researchers measured BHB from different blood sampling sites and checked EPO, estradiol, and ferritin levels. The goal was to understand ketosis effects on these markers, not to treat any disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketone monoester dietary supplement
What this could lead to
If successful, this could help researchers understand how ketosis influences erythropoietin and hormone levels, potentially guiding future studies on metabolic health.
What could go wrong
This is a small, early-stage study with only 16 healthy participants, so results may not apply to broader populations or have direct clinical impact.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Aug 2023

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-60 years * BMI 19-30 kg/m2 * Expected ease of catheter insertion * Considered of sound health * Oral and written informed consent Exclusion Criteria: * Inability to fully understand the consent including consent forms * Inability to cooperate to the study * electrolyte disorders * acute or chronic kidney disease or ompromised renal function including excess risk * servere hypertension * autoimmune disease * liver or bile disease * diabetes mellitus * reactive hypoglycemia or similar disorders * treatment with drugs, and dietary supplements with inference on key metabolic or hormonal markers, e.g. insulin, glucagon, DDP-IV inhibitors, GLP-1 RA, sulfunylurea * use of illegal or otherwise use of medicinal products without prescription * anemia or other know disease of the hematopoietic system * previous bariatric surgery * previous myocardial infarction or uncontrolled myocardial ischemia * recent intended/unintended weight loss * allergies to catheters or adhesives

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Conditions

The condition(s) this trial relates to.

Ketosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ketosis

Contacts and locations

Locations

  • Department of Internal Medicine, Viborg Regional Hospital

    Viborg, 8800, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.