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Ketone drink study reveals surprising effects on blood sugar and liver fat

NCT ID NCT06320522

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how a ketone drink changes blood sugar and liver fat production in 12 healthy adults, comparing when they were fasted versus after a meal. Researchers wanted to understand if the drink's effects differ based on whether you've just eaten. The goal is to learn more about how ketones might help with conditions like fatty liver disease and type 2 diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Feb 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Habitually consuming a mixed macronutrient diet * Fluent in English, no communication impairments, willing \& able to give informed consent for participation in the study * Not currently taking any medication (except the contraceptive pill) * No food allergies incompatible with the supplement drinks or with the standardised breakfast where a suitable substitution cannot be practically made * Female-only - on contraception (pill/implant/coil/etc); not pregnant/currently breastfeeding; pre-menopausal; not undertaking hormone replacement therapy (HRT) * In the investigator's opinion - able and willing to comply with all study requirements Exclusion Criteria: * Significant cardiovascular disease or metabolic risk factors, or family history of it, on health screening questionnaire * Food allergies incompatible with the supplement drinks or standardised breakfast * Having been on a ketogenic diet in the 6 months prior to enrolment * Any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study/the participant's ability to participate in the study * Concurrently a participant in any other dietary intervention study/have taken part in one within 1 month of enrolment * Diabetic * Pregnant or breastfeeding * Known history of moderate-to-severe motion sickness

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Conditions

The condition(s) this trial relates to.

Ketosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exogenous ketosis Ketosis

Contacts and locations

Locations

  • Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM)

    Oxford, Oxfordshire, OX3 7LE, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.