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Could a simple pain shot improve IVF recovery without hurting success?

NCT ID NCT07185724

Symptom relief Sponsor: Jessica D. Kresowik Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving the painkiller ketorolac after egg retrieval can safely reduce pain without lowering the chance of pregnancy in fresh embryo transfers. About 200 IVF patients will be randomly assigned to receive either ketorolac or no ketorolac after their egg retrieval. The researchers will compare implantation rates, pain levels, and live birth rates between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketorolac (a nonsteroidal anti-inflammatory drug given by IV)
What this could lead to
If it works, this could show that ketorolac is a safe and effective painkiller for women having fresh embryo transfers after egg retrieval.
What could go wrong
This is a single, mid-sized trial. Earlier studies were mixed, and there is still a theoretical risk that ketorolac could affect implantation or increase bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 37 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * IVF utilizing autologous oocytes and all sperm sources * IVF cycles utilizing ICSI and standard insemination * Plan to transfer embryo on day 5 * BMI below 50 Exclusion Criteria: -allergies or medical contraindications to NSAIDs

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Conditions

The condition(s) this trial relates to.

infertility disorder Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fresh embryo transfer Infertility (ivf patients) Infertility treatment Oocyte retrieval and post operative pain control Post-op pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UI Health Care Center for Advanced Reproductive Care

    RECRUITING

    Iowa City, Iowa, 52245, United States

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