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Ketone drink shows promise for heart failure in small study

NCT ID NCT05651529

Symptom relief Sponsor: Université de Sherbrooke Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single dose of a ketone salt supplement could improve heart function in 20 people with stable heart failure. Participants took either the ketone supplement or a carbohydrate placebo before a heart MRI. The goal was to see if the supplement could help the heart pump more effectively.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exogenous ketone salt supplement
What this could lead to
If it works, this could point toward a simple dietary supplement to help improve heart function in people with heart failure.
What could go wrong
This is a very small, early-stage study with only 20 participants. The supplement was taken just once, so any effects may be temporary or not meaningful in the long run.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Dec 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with heart failure with left ventricle ejection fraction of 40% * Heart failure of ischemic or dilated etiology * Ambulatory patient with a NYHA functional class of II-III; * Stable symptoms and no change in medical therapy in the last month. Exclusion Criteria: * Diabetes * Patients treated with any SGLT2i; * Chronic kidney disease * Acute coronary syndrome in the last 3 months; * Use of parenteral inotropic agents; * Persistent or permanent atrial fibrillation or atrial flutter; * Presence of pacemaker or defibrillator; * Medical condition that causes malabsorption of the test material; * Under ketogenic diet, or using exogenous ketone supplements * Use of nicotinamide adenine dinucleotide (NAD) precursor supplements

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Conditions

The condition(s) this trial relates to.

heart failure Ketosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

Contacts and locations

Locations

  • Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Centre Hospitalier Universitaire de Sherbrooke, departement de médecine

    Sherbrooke, Quebec, J1H 5N4, Canada

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