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Ketone drink may alter Alcohol's effects, small study hints
NCT ID NCT05551754
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This study looks at whether taking a ketone supplement before drinking alcohol changes how drunk people feel or how alcohol shows up in their breath or blood. Ten healthy volunteers will drink alcohol on two separate days, once with the supplement and once with a placebo. The goal is to understand if ketones can alter the body's response to alcohol, which could lead to future treatments for alcohol-related problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2022
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Willingness to provide signed, informed consent and commit to completing the alcohol lab studies. 2. All subjects must report at least one occasion in the prior month of drinking at least 2 drinks on a single day. Exclusion Criteria: 1. Unwilling or unable to refrain from use, within 24 hours of alcohol lab procedures, psychoactive medications or medications that may affect study results. 2. Current DSM-5 diagnosis of a major psychiatric disorder (other than nicotine use disorders, or marijuana use disorders) (identified by clinical examination or the structured interview) that could interfere with study participation or make it hazardous for the subject. 3. Currently taking a medication that could interfere with study participation or make it hazardous for the subject to participate. (e.g., anticholinergics; antipsychotics; lithium; psychotropic drugs not otherwise specified) 4. Positive urine drug screen positive for all substances but marijuana on study visits (may be repeated once and if the result is negative on repeat it is not exclusionary). 5. A baseline breath alcohol concentration of greater than 0.00% on study visit prior to alcohol tolerance test 6. A current, clinically significant physical disease or abnormality on the basis of medical history, or routine laboratory evaluation that can impact brain function, the use of a ketone supplement or the use of alcohol (e.g., epilepsy, diabetes, irritable bowel syndrome, Crohn's disease, liver disease, kidney disease, kidney stones, chronic metabolic acidosis or a cardiomyopathy as determined by history and clinical exam). 7. Currently suffering from or with a history of stroke and/or stroke related spasticity. 8. Head trauma with loss of consciousness for more than 30 minutes or associated with skull fracture or inter-cranial bleeding or abnormal MRI. (self-report, medical history). 9. Weight greater than 225lbs (Need to cap amount of alcohol give based on weight to individuals). 10. Judged by the principal investigator or his designee to be an unsuitable candidate for study participation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Pennsylvania Center for Studies of Addiction
Philadelphia, Pennsylvania, 19104, United States
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Other studies related to the condition(s) this trial covers.
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