Sip your way sharper? ketone drink tested against sleep loss
NCT ID NCT05519644
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a ketone ester supplement can help people think clearly and perform physical tasks after four nights of reduced sleep. Researchers will give the drink to 60 military participants and measure their cognitive skills, reaction time, and marksmanship. The goal is to see if raising blood ketones can offset some of the negative effects of sleep deprivation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ketone ester supplement
- What this could lead to
- If it works, this could point toward a simple drink that helps people stay sharp and accurate during short-term sleep loss.
- What could go wrong
- This is a small, early-stage study in healthy military personnel, so results may not apply to the general public. The supplement may not improve performance or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2023
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participant is willing and able to comply with all study procedures including the following prior to Test Days: fasting (\>10 h; water only), no alcohol (\>24 h), no exercise (\>24 h), no acute illness and controlled feeding before each Test Day, maintain diet, exercise, medication, and supplement habits throughout the study. * Participant has no health conditions that would prevent completion of the study requirements as judged by the Investigator based on health history. * Participant understands the study procedures and signs forms providing informed consent to participate in the study and authorizes the release of relevant protected health information to the Investigator. Exclusion Criteria: * \<18 or \>40 years of age * \>35 body mass index (BMI). * Diagnosed sleeping disorders (i.e., sleep apnea, insomnia). * Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements. * Drink alcohol in excess of 3 drinks/day or 14 drinks/week * Have any conditions or contraindications to blood draws. * Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin * Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months * Have experienced weight loss of \>10% of your body weight within the last 6 months * Are pregnant, lactating, or planning on becoming pregnant during the study * Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Ohio State University
Columbus, Ohio, 43210, United States
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Other studies related to the condition(s) this trial covers.
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