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Sip your way sharper? ketone drink tested against sleep loss

NCT ID NCT05519644

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a ketone ester supplement can help people think clearly and perform physical tasks after four nights of reduced sleep. Researchers will give the drink to 60 military participants and measure their cognitive skills, reaction time, and marksmanship. The goal is to see if raising blood ketones can offset some of the negative effects of sleep deprivation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketone ester supplement
What this could lead to
If it works, this could point toward a simple drink that helps people stay sharp and accurate during short-term sleep loss.
What could go wrong
This is a small, early-stage study in healthy military personnel, so results may not apply to the general public. The supplement may not improve performance or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2023

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is willing and able to comply with all study procedures including the following prior to Test Days: fasting (\>10 h; water only), no alcohol (\>24 h), no exercise (\>24 h), no acute illness and controlled feeding before each Test Day, maintain diet, exercise, medication, and supplement habits throughout the study. * Participant has no health conditions that would prevent completion of the study requirements as judged by the Investigator based on health history. * Participant understands the study procedures and signs forms providing informed consent to participate in the study and authorizes the release of relevant protected health information to the Investigator. Exclusion Criteria: * \<18 or \>40 years of age * \>35 body mass index (BMI). * Diagnosed sleeping disorders (i.e., sleep apnea, insomnia). * Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements. * Drink alcohol in excess of 3 drinks/day or 14 drinks/week * Have any conditions or contraindications to blood draws. * Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin * Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months * Have experienced weight loss of \>10% of your body weight within the last 6 months * Are pregnant, lactating, or planning on becoming pregnant during the study * Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)

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Conditions

The condition(s) this trial relates to.

Sleep Deprivation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The Ohio State University

    Columbus, Ohio, 43210, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.