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Antifungal cream could be new acne treatment

NCT ID NCT07237763

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a common antifungal cream, ketoconazole, can treat mild acne as well as a standard retinoid cream, adapalene. Fifty-two people with mild acne will use one of the two creams for 12 weeks. Researchers will count pimples and check for side effects to see if ketoconazole is a good alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketoconazole 2% cream
What this could lead to
If ketoconazole works as well as adapalene with fewer side effects, it could offer a gentler option for treating mild acne.
What could go wrong
This is a small, early-stage trial with only 52 people, so results may not apply to everyone. Ketoconazole is an antifungal, not a standard acne treatment, so it may not be effective for all acne types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 52 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with mild comedonal or papulopustular acne with a GEA score from 1-2 on the face. * Both sexes. * Age: adolescents and adults. * Skin type 3 and 4. Exclusion Criteria: * • Patients using, will use during the study, or discontinued less than 4 weeks before study baseline, prescribed or over-the counter topical therapies for the treatment of acne. * Patients using, will use during the study, or discontinued less than 4 weeks before study baseline, any facial procedures such as chemical peel, laser treatment or depilation in area of treatment application (except eyebrow shaping). * Patients with outdoor occupation, exposed to sun and heat. * Patients using, will use during study any cosmoceuticals. * Patients using, will use during the study, or discontinued less than 12 weeks before study baseline, systemic therapies for the treatment of acne or any other systemic treatments. * Patients with other special types of acne or conditions presenting with acne/acneiform eruption. * Irregular menstrual cycles or clinically suspected polycystic ovarian syndrome. * Patients with other facial rashes preventing the accurate assessment. * Known or suspected allergy to ingredients. * Pregnancy or lactation.

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Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acne

Contacts and locations

Locations

  • Cairo university

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.