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Could a single ketamine shot curb suicidal urges in the ER?

NCT ID NCT06085937

Symptom relief Sponsor: Lindsay Maguire, MD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether a single low-dose injection of ketamine is safe and practical for adults who come to the emergency department with severe suicidal thoughts. Researchers will monitor side effects and ask staff about their experience. If successful, it could offer a quick way to ease suicidal thinking while patients wait for psychiatric help.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine
What this could lead to
If it works, this could provide a fast-acting option to reduce suicidal thoughts in the emergency room, buying time for further psychiatric care.
What could go wrong
This is a very early Phase 1 trial with only 50 participants, so it may not prove effective or safe for broader use. Ketamine can cause side effects like dissociation or blood pressure changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category) * Require inpatient stabilization for SI or actions based on clinical observation and interview * Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus * Have a Glasgow Coma Score (GCS) of 15 * Age 18-65 Exclusion Criteria: * Current or past history of psychosis * Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater * History of ketamine use disorder * History of liver transplant * Pregnancy or breastfeeding * Imprisonment or inability to consent * Positive urine drug screen or serum alcohol level * Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine) * Hypotension (SBP \< 90) * Presence of acute medical condition requiring admission to medical service * Allergy, intolerance, or previous adverse reaction to ketamine * Patient has 8+ lifetime ketamine exposures * The treating physician determines that the patient is not a good candidate for the study (e.g. medical condition/procedure, medication that would contradindicate ketamine treatment)

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Suicidal Ideation Suicide

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Suicidal ideation Suicide

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Kansas Medical Center Emergency Department

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Kansas Strawberry Hill Campus

    NOT_YET_RECRUITING

    Kansas City, Kansas, 66101, United States

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