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Could a ketamine injection during jaw surgery cut Post-Op pain?

NCT ID NCT07066306

Symptom relief Sponsor: Bezmialem Vakif University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting a low dose of ketamine directly into the jaw during surgery can reduce pain, swelling, and nausea afterward. Forty adults having corrective jaw surgery will receive either ketamine plus standard anesthetic or standard anesthetic alone. Researchers will measure pain scores, swelling, and the need for extra pain medicine over the first week.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine
What this could lead to
If it works, this could offer a simple way to reduce pain and swelling after jaw surgery without strong side effects.
What could go wrong
This is a small, early-stage study with only 40 people, so results may not apply widely. Ketamine can cause side effects like dizziness or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with Class II or Class III skeletal deformities who underwent bimaxillary orthognathic surgery due to dentofacial deformities. 2. ASA I-II physical status patients. 3. Patients aged between 18 and 45 years. 4. Patients who received anesthesia induction and maintenance with propofol (0.2-0.6 mg/kg/hour) titrated to maintain an entropy score between 40-60, and remifentanil (0.05-0.5 mg/kg/hour) adjusted to maintain a Surgical Pleth Index (SPI) between 20-50. 5. Patients who received a combination of local anesthetic and ketamine. 6. Patients who were administered patient-controlled analgesia (PCA) at the end of the surgery and whose opioid consumption via PCA was monitored during the first 24 hours postoperatively. 7. Patients whose nausea-vomiting scores and need for antiemetics were recorded. 8. Patients with complete documentation of anesthesia records, including entropy scores, SPI values, and total doses of propofol and remifentanil administered. 9. Patients with completed postoperative edema follow-up forms. Exclusion Criteria: 1. Patients with a known allergy to ketamine. 2. Patients with uncontrolled systemic diseases. 3. Patients using psychotropic medications. 4. Patients with a history of substance abuse. 5. Patients with chronic pain lasting longer than 3 months. 6. Patients using analgesic or hypnotic medications for more than 2 weeks. 7. Cases in which complications occurred during surgery that required deviation from the standard orthognathic surgical protocol and could potentially affect postoperative pain levels (e.g., bad split, unexpectedly prolonged surgical duration, etc.).

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Conditions

The condition(s) this trial relates to.

agnosia Dentofacial Deformities Nausea pain agnosia Postoperative Nausea and Vomiting Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Dentofacial deformities Nausea, postoperative Vomiting, postoperative

Contacts and locations

Locations

  • Bezmialem Vakıf Universty

    Istanbul, Fatih, 34093, Turkey (Türkiye)

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