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Could a Ketamine-Buprenorphine combo rapidly stop suicidal thoughts?

NCT ID NCT04116528

First seen Jun 01, 2026 · Last updated Jun 17, 2026 · Updated 5 times

Summary

This study looked at whether adding buprenorphine to ketamine treatment can reduce suicidal thoughts faster and longer in adults with major depression. About 50 people took part. Researchers measured changes in suicidal thinking over several weeks to see if the combination worked better than ketamine alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Stanford University School of Medicine

    Stanford, California, 94305, United States

Conditions

The condition(s) this trial relates to.

bipolar II disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.