New hope for kids with rare leukemia: targeted drug combo enters trial
NCT ID NCT05849662
First seen Apr 17, 2026 · Last updated May 25, 2026 · Updated 6 times
Summary
This study tests a new treatment plan for children with juvenile myelomonocytic leukemia (JMML), a rare blood cancer. Lower-risk patients receive two drugs (trametinib and azacitidine), while higher-risk patients get those plus chemotherapy. The goal is to see if the combinations are safe and help control the disease. About 58 children and young adults up to age 21 will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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C.S. Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 900027, United States
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Children's Hospital of Atlanta
RECRUITINGAtlanta, Georgia, 30322, United States
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Children's Hospital of Colorado
RECRUITINGDenver, Colorado, 80045, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Mercy Hospital
RECRUITINGKansas City, Missouri, 64108, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Indiana University/Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
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Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Sidney Kimmel Cancer Center at Johns Hopkins
RECRUITINGBaltimore, Maryland, 21231, United States
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St. Jude Children's Research Hospital Memphis
RECRUITINGMemphis, Tennessee, 38105, United States
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University of California San Francisco
RECRUITINGSan Francisco, California, 94158, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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Conditions
Explore the condition pages connected to this study.