New hope for kids with rare leukemia: drug combo trial launches
NCT ID NCT05849662
First seen Apr 17, 2026 · Last updated May 13, 2026 · Updated 4 times
Summary
This study tests two drugs, trametinib and azacitidine, with or without chemotherapy, in children and young adults newly diagnosed with juvenile myelomonocytic leukemia (JMML), a rare blood cancer. Lower-risk patients get the two-drug combo; higher-risk patients also get two additional chemotherapy drugs. The goal is to find safe doses and see if the treatment works, though lifelong monitoring or further therapy may still be needed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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C.S. Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 900027, United States
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Children's Hospital of Atlanta
RECRUITINGAtlanta, Georgia, 30322, United States
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Children's Hospital of Colorado
RECRUITINGDenver, Colorado, 80045, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Mercy Hospital
RECRUITINGKansas City, Missouri, 64108, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Indiana University/Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
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Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Phoenix Children's Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Sidney Kimmel Cancer Center at Johns Hopkins
RECRUITINGBaltimore, Maryland, 21231, United States
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St. Jude Children's Research Hospital Memphis
RECRUITINGMemphis, Tennessee, 38105, United States
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University of California San Francisco
RECRUITINGSan Francisco, California, 94158, United States
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University of Miami
RECRUITINGMiami, Florida, 33136, United States
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Conditions
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