New combo therapy may beat stubborn fungal infections
NCT ID NCT07420894
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding isotretinoin (a retinoid that changes skin oil and growth) to the standard antifungal itraconazole works better than itraconazole alone for adults with resistant Trichophyton fungal skin infections. 148 adults aged 18-65 with confirmed infection were randomly assigned to one of two groups. The goal was to see if the combination leads to higher cure rates and fewer relapses.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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148 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 to 65 years * Clinical features suggestive of dermatophytosis * Laboratory-confirmed Trichophyton infection at baseline * Provision of written informed consent * Ability and willingness to comply with treatment, follow-up visits, and required laboratory monitoring Exclusion Criteria: * Negative potassium hydroxide microscopy and no culture evidence of Trichophyton infection at baseline * Infection caused by non-Trichophyton dermatophytes on culture, or no growth on culture where culture is used for confirmation * Use of additional systemic antifungal therapy during the treatment period (not permitted by protocol) * Use of systemic retinoids other than study-assigned isotretinoin during the treatment period (not permitted by protocol) * Pregnancy at baseline in women of childbearing potential, or inability or unwillingness to follow strict pregnancy avoidance requirements during and after isotretinoin therapy * Any contraindication to itraconazole or isotretinoin, including known hypersensitivity to either drug * Clinically significant baseline liver dysfunction or abnormal liver function tests considered unsafe for systemic itraconazole and or isotretinoin use
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Multan Medical and Dental College
Multan, Punjab Province, 60000, Pakistan
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Other studies related to the condition(s) this trial covers.