Pediatric GVHD drug combo trial halted early after just 2 kids enrolled
NCT ID NCT03721965
First seen Nov 05, 2025 · Last updated May 20, 2026 · Updated 24 times
Summary
This study tested a drug called itacitinib combined with steroids to treat a serious complication of stem cell transplants called acute graft-versus-host disease (aGVHD) in children. The trial aimed to see if the combination was safe and effective for kids aged 28 days to under 18 years. However, the study was stopped early after enrolling only 2 participants, so no firm conclusions can be drawn.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita
Torino, 10126, Italy
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Azienda Ospedaliero Unversitatia Policlinico - Vittorio Emanuele - Presido Ospedaliero G. Rodolico
Catania, 95123, Italy
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Birmingham Childrens Hospital
Birmingham, B4 6NH, United Kingdom
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Bristol Royal Hospital for Children
Bristol, BS2 8BJ, United Kingdom
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CHRU Nancy
Vandœuvre-lès-Nancy, 54500, France
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CHU Nancy
Vandœuvre-lès-Nancy, 54500, France
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CHU de Grenoble
Grenoble, 38043, France
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CHU de Grenoble
Grenoble, 38403, France
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Central Manchester University Hospital - Royal Manchester Children's Hospital
Manchester, M13 9WL, United Kingdom
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Centre Hospitalier Universitaire de Rennes
Rennes, Cedex 2, 35203, France
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Children's Hospital Colorado - Center for Cancer and Blood Disorders
Aurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia - Center for Childhood Cancer Research
Philadelphia, Pennsylvania, 19104, United States
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Childrens Hospital of Orange County
Orange, California, 92868, United States
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City of Hope National Medical Center
Duarte, California, 91010, United States
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Doernbecher Children's Hospital - Division of Pediatric Hematology
Portland, Oregon, 97239, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Fondazione MBBM
Monza, 20900, Italy
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Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024, United States
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Great Ormond Street Hospital for Children
London, WC1N 3JH, United Kingdom
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Hopitaux Universitaires De Strasbourg
Strasbourg, Cedex, 67098, France
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Hopitaux Universitaires De Strasbourg
Strasbourg, 67098, France
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Hospital Clinico de Santiago de Compostela
Santiago de Compostela, 15706, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Vall D Hebron
Barcelona, 08035, Spain
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Leeds Teaching Hospitals NHS Trust
Leeds, LS13EX, United Kingdom
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Nemours/A.I. duPont Hospital for Children
Wilmington, Delaware, 19803, United States
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Nicklaus Children's Hospital
Miami, Florida, 33155, United States
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Ospedale Pediatrico Bambino Gesu
Roma, 00165, Italy
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Policlinico S. Orsola-Malpighi
Bologna, 40138, Italy
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Robert Debre Hospital
Paris, 75019, France
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Royal Marsden Hospital - Surrey
Surrey Quays, SM2 5PT, United Kingdom
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Sarah Cannon Research Institute, LLC
Nashville, Tennessee, 37203, United States
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Universitaetsklinikum Aachen, AoeR
Aachen, 52074, Germany
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Universitatsklinikum Jena, Klinik fur Kinder und Jugendmedizin
Jena, 07747, Germany
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University Hospitals Cleveland Medical Center - Rainbow Babies and Children's Hospital
Cleveland, Ohio, 44106, United States
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University of Minnesota Medical Center
Minneapolis, Minnesota, 55454, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232-6868, United States
Conditions
Explore the condition pages connected to this study.