Stitch showdown: which way to sew a uterine scar works best?
NCT ID NCT07625852
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways of stitching the uterine wall after laparoscopic isthmocele repair: vertical closure (along the uterus) vs. transverse closure (across it). The goal is to see which method leads to a thicker, stronger scar and better symptom relief. The trial will enroll 72 women with symptomatic isthmocele and follow them for 12 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- surgical closure technique (vertical or transverse suturing)
- What this could lead to
- If successful, this could identify the better surgical method for repairing isthmocele, potentially reducing symptom recurrence and improving fertility outcomes.
- What could go wrong
- This is a small, early-stage trial with only 72 participants, so results may not apply widely. Both techniques are already used, so no major breakthrough is expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 72 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women aged 18-45 years. * Diagnosis of symptomatic isthmocele confirmed by transvaginal ultrasound (myometrial thickness at the defect \< 2.5 mm). * History of at least one prior cesarean section. * Symptoms attributable to isthmocele (e.g., abnormal uterine bleeding, pelvic pain, dysmenorrhea, secondary infertility). * Desire for surgical correction of isthmocele. * Ability to understand and provide informed consent Exclusion Criteria: * Asymptomatic isthmocele. * Active pelvic infection or malignancy. * Significant medical comorbidities contraindicating laparoscopic surgery. * Coagulopathy. * Known uterine anomalies (e.g., bicornuate uterus). * Pregnancy at the time of recruitment. * Inability to comply with follow-up protocol.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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