Can a better rinse ease root canal pain?

NCT ID NCT07599254

Symptom relief Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two different irrigation techniques used during root canal retreatment to see which one leads to less pain afterward. About 100 adults with a previous root canal and ongoing infection will take part. The goal is to find a simple way to improve comfort after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: root canal irrigation solutions
What this could lead to: If successful, this could point to a better way to manage pain after root canal retreatment.
What could go wrong: This is a small, early-phase study focused on pain, not a cure. Results may not apply to all teeth or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * o Patients aged 18-60 years who are classified as medically healthy (ASA I or II), * Mature, single-rooted and canal teeth that had root canal treatment at least four years ago, * Teeth with previous root canal obturation 2-4 mm short of the apex, * Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 , * Teeth with single root and canal diagnosed with asymptomatic apical periodontitis, * Teeth suitable for rubber dam isolation. Exclusion Criteria: * o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment, * Teeth exhibiting periodontal attachment loss, * Presence of vertical root fractures, external root resorption, or perforations, * Teeth with retained broken instruments, * Non-restorable teeth, * Patients in the pregnancy and breastfeeding period.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Apical periodontitis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can a better rinse ease root canal pain?

What the study statuses mean