Tailored ventilation strategy fails to prove benefit in Early-Stopped lung trial
NCT ID NCT04012073
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 31 times
Summary
This study tested whether adjusting a breathing machine's pressure based on each patient's lung volume could improve outcomes for adults with moderate-to-severe acute respiratory distress syndrome (ARDS). The trial planned to enroll many patients but was stopped early after only 18 participants. The approach aimed to reduce inflammation, time on a ventilator, and death in the ICU, but the early termination means no firm conclusions can be drawn.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Azienda ospedaliera universitaria di Ferrara-arcispedale Sant'Anna
Ferrara, Italy
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Azienda ospedaliero-universitaria Mater Domini
Catanzaro, Italy
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Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
Milan, Italy
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Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
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Fondazione Policlinico Universitaro A. Gemelli IRCCS
Rome, Italy
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Ospedale San Gerardo
Monza, Italy
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Ospedale San Martino
Genova, Italy
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Policlinico Sant'Orsola
Bologna, Italy
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Policlinico di Bari
Bari, Italy
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SS. Annunziata hospital
Chieti, Italy
Conditions
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