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New injection combo eases severe knee pain without surgery

NCT ID NCT07269444

Symptom relief Sponsor: Kanuni Sultan Suleyman Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a special numbing injection (IPACK block) combined with a steroid shot can reduce pain in people with advanced knee osteoarthritis. 98 adults over age 40 with severe knee pain despite other treatments received the combination. Researchers measured pain levels before and one month after the injection to see if it helped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

98 people

The number who actually took part.

Started

Dec 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting to a tertiary hospital in Istanbul, Turkey, with knee pain and diagnosed with stage 3-4 knee osteoarthritis based on clinical and radiological findings between January 2024 and September 2025 were included in the study. The procedure was performed on a single knee, and the contralateral knee was not treated.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients over 40 years of age * Diagnosed with primary knee osteoarthritis according to ACR (American College of Rheumatology) criteria based on clinical, radiological, and laboratory evaluations * Activity VAS score of 5 or higher despite previous medical and physical therapy * Patients with stage 3-4 knee osteoarthritis according to the Kellgren-Lawrence classification * Patients without motor or sensory loss on neurological examination * Patients who signed an informed consent form * Patients who have not undergone any interventional procedures on the knee within the last 6 months Exclusion Criteria: * Patients with bleeding or coagulation disorders * Patients with sepsis or local infection at the intervention site * Patients with allergies to any of the medications to be used * Patients without study consent * Patients with secondary osteoarthritis * Patients who have undergone knee interventions in the last 6 months * Patients who have undergone knee surgery * Psychosis

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intraarticular injection Ipack block multimodal analgesia Knee osteoarthritis (knee oa) Ultrasound guided injection

Contacts and locations

Locations

  • Kanuni Sultan Süleyman Training and Research Hospital

    Küçükçekmece, Istanbul, (507) 277-4773, Turkey (Türkiye)

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