Nasal spray may stop Epidural-Related fever in childbirth
NCT ID NCT07501221
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of dexmedetomidine nasal spray, given before an epidural, can prevent fever during labor. 446 women having vaginal deliveries will be randomly assigned to receive either the drug or a placebo. The goal is to see if this simple approach reduces the risk of fever, which can cause complications for both mother and baby.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dexmedetomidine nasal spray
- What this could lead to
- If it works, this could offer a simple, non-invasive way to prevent fever during labor, improving safety for mothers and babies.
- What could go wrong
- This is an early-stage trial with a moderate number of participants. The effect may be small or not work at all, and there are risks like low heart rate or low blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 446 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ASA physical status II or III * Age ≥ 18 years * Singleton pregnancy, cephalic presentation * No contraindications to neuraxial anesthesia and voluntarily requesting labor analgesia Exclusion Criteria: * Maternal temperature ≥ 37.3°C before labor analgesia * Allergy to α2-adrenergic receptor agonists * Severe pregnancy complications or systemic diseases * Use of analgesics, nonsteroidal anti-inflammatory drugs, or other medications that may affect body temperature within one week prior to enrollment * Heart rate \< 60 bpm or systolic blood pressure \< 90 mmHg before labor analgesia * Severe rhinitis or nasal deformity * Premature rupture of membranes
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Chengdu Jinjiang District Women & Children Health Hospital
Chengdu, Sichuan, 610011, China
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