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Can a simple fat infusion wake up numb skin faster?

NCT ID NCT03968822

Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether an intravenous fat emulsion called Intralipid 20% can reverse the numbing effect of common local anesthetics like lidocaine and bupivacaine. Eighteen healthy volunteers receive small injections of these anesthetics in their thigh, followed by either Intralipid or a saline placebo. Researchers measure how quickly normal sensation returns to see if Intralipid speeds up recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intralipid 20% (fat emulsion given intravenously)
What this could lead to
If it works, this could provide a way to speed up recovery from local anesthesia after procedures.
What could go wrong
This is a small, early proof-of-concept study in healthy volunteers, not patients. Results may not apply to real-world medical situations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * English speaking * BMI 18-25, with body weight between 50-100kg Exclusion Criteria: * ASA III or higher * Pregnant Women * Allergy to study medications (lidocaine, bupivacaine, soybeans, eggs) * Use of drugs affecting the sensorium (including opioids, benzodiazepines, antipsychotics, gabapentinoids)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia, local

Contacts and locations

Locations

  • Hospital of Special Surgery

    New York, New York, 10021, United States

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