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Fasting or lifting weights: which works better for PCOS?

NCT ID NCT06882291

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compared two lifestyle approaches—intermittent fasting (eating only during an 8-hour window) and resistive exercise (like weight training)—for improving insulin resistance in 72 obese women with polycystic ovary syndrome (PCOS). The goal was to see which method is more effective. Participants were followed for 8 weeks, and researchers measured changes in insulin resistance and waist size.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intermittent fasting diet and resistive exercise program
What this could lead to
If successful, this could show that intermittent fasting or resistive exercise is a practical way to improve insulin resistance in obese women with PCOS, potentially guiding future lifestyle-based treatments.
What could go wrong
This is a small, completed study with only 72 participants, so results may not apply to all women with PCOS. Also, lifestyle interventions can be hard to maintain long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Mar 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Seventy two obese women diagnosed with Polycystic ovarian syndrome by the gynecologist (based on the Rotterdam diagnostic criteria) * Their age will range from 25 to 40 years old. * Overweight or obese (BMI \>25 kg/m2 and \< 30 kg/m2). Exclusion Criteria: * The presence of diseases (such as congenital adrenal hyperplasia, Cushing syndrome, androgen secreting tumors, hyperprolactinemia, diabetes, thyroid diseases, Severe serious cardiovascular, gastrointestinal, kidney and liver diseases. premature ovarian failure, hypothalamic/pituitary disease * Hormonal contraceptive use. * Participants who did not complete the study were excluded from the analysis. * Use of medication therapy that impacts carbohydrate or lipid metabolism (oral contraceptive pills, insulin sensitizers, anti epileptics, anti psychotics, statins, and fish oil) in the recent 6 months; * Body weight fluctuations for more than 5% in the past 3 months; in preparation for pregnancy. * Perimenopausal; night shift workers; fasting for more than 16 h per day; hypotension * Alcohol intake for more than 100 g per week; smoking within the past 3 months * Engaging in high intensity exercise.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polycystic ovary syndrome

Contacts and locations

Locations

  • Mashtoul Elsouq general Hospital

    ‘Ezbet el-Sharika el-Miṣrîya, Egypt

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