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Breathing gas after heart surgery may stop deadly lung infection

NCT ID NCT06261827

Prevention Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether breathing high-dose nitric oxide (NO) gas for 30 minutes twice a day for 5 days after heart surgery could prevent hospital-acquired pneumonia. 160 adults who had elective heart surgery with a heart-lung machine took part. Half received NO, half received a placebo (oxygen-air mixture). The goal was to see if NO lowers pneumonia rates and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nitric oxide (NO) gas
What this could lead to
If it works, this could offer a simple way to prevent a serious lung infection after heart surgery.
What could go wrong
This is a small, single-center study with no phase designation, so results may not apply widely. High-dose NO can have side effects like methemoglobinemia or lung irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

160 people

The number who actually took part.

Started

Feb 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Cardiac surgery with CPB at current hospitalization. 2. Age \> 18 years. 3. Signed informed consent Exclusion Criteria: 1. Emergency surgery. 2. Acute coronary syndrome 30 days before surgery. 3. Surgery for active infective endocarditis requiring antibiotic therapy. 4. Diagnosed infectious process of another localization (surgical site infection (SSI), acute and chronic urinary tract infection (active), catheter-related bloodstream infection, peritonitis, etc.). 5. Taking antibacterial drugs for 14 days preceding surgery 6. Other complications of the postoperative period (pneumothorax requiring pleural drainage, perioperative myocardial infarction accompanied by pulmonary edema, shock of any etiology during the current hospitalization). 7. Potentially dialysis-dependent stage 2 and higher acute kidney injury (according to KDIGO) in the early postoperative period (the criteria for potentially dialysis-dependent acute kidney injury will include patients with stage 2 acute kidney injury and: oliguria against the background of normo-hypervolemia and resistance to loop diuretics and/ or oliguria against the background of conducting infusion therapy due to hypovolemia and resistance to loop diuretics). 8. Continued mechanical ventilation. 9. Delirium. 10. Presence of tracheostomy. 11. Patient's participation in another clinical trial at the time of screening or within the previous 3 months. 12. Concomitant pulmonary disease with the need for respiratory support before surgery. 13. History of malignancy or other irreversible diseases/conditions with a 6- month mortality rate \>50%.

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Conditions

The condition(s) this trial relates to.

Healthcare-Associated Pneumonia nosocomial infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nosocomial pneumonia

Contacts and locations

Locations

  • Cardiology Research Institute Tomsk national Research Medical Center

    Tomsk, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.