Can a simple gas stop pneumonia after heart surgery?
NCT ID NCT06162455
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether breathing in high-dose nitric oxide (NO) gas after heart surgery could prevent pneumonia. 74 patients who had heart surgery with a heart-lung machine were randomly assigned to receive either NO gas or a placebo (oxygen-air mixture) for 30 minutes twice a day for 5 days. The researchers measured how many patients developed pneumonia in each group.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Nitric Oxide (NO) gas
- What this could lead to
- If it works, this could offer a simple way to prevent pneumonia after heart surgery, reducing complications and hospital stays.
- What could go wrong
- This is a small pilot study with only 74 participants, so results may not be definitive. The treatment requires inhaling gas twice daily for 5 days, which may be inconvenient.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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74 people
The number who actually took part.
- Started
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Nov 2023
- Finished
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Feb 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Cardiac surgery with CPB at current hospitalization. 2. Age \> 18 years. 3. Signed informed consent. 4. The presence of at least one risk factor for the development of postoperative NP (CPB time ≥ 96 minutes and/or mechanical ventilation ≥ 14 hours and/or atrial fibrillation before surgery). Exclusion Criteria: 1. Emergency surgery. 2. Acute coronary syndrome 30 days before surgery. 3. Surgery for active infective endocarditis requiring antibiotic therapy. 4. Diagnosed infectious process of another localization (surgical site infection (SSI), acute and chronic urinary tract infection (active), catheter-related bloodstream infection, peritonitis, etc.). 5. Taking antibacterial drugs for 14 days preceding surgery. 6. Other complications of the postoperative period (pneumothorax requiring pleural drainage, perioperative myocardial infarction accompanied by pulmonary edema, shock of any etiology during the current hospitalization). 7. Potentially dialysis-dependent stage 2 and higher acute kidney injury (according to KDIGO) in the early postoperative period (the criteria for potentially dialysis-dependent acute kidney injury will include patients with stage 2 acute kidney injury and: oliguria against the background of normo-hypervolemia and resistance to loop diuretics and/or oliguria against the background of conducting infusion therapy due to hypovolemia and resistance to loop diuretics). 8. Continued mechanical ventilation. 9. Delirium. 10. Presence of tracheostomy. 11. Patient's participation in another clinical trial at the time of screening or within the previous 3 months. 12. Concomitant pulmonary disease with the need for respiratory support before surgery. 13. History of malignancy or other irreversible diseases/conditions with a 6-month mortality rate \>50%. 14. Presence of HIV infection.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cardiology Research Institute Tomsk National Research Medical Center
Tomsk, Select..., 634012, Russia
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