Breathing easy: inhaled antibiotic may stop ventilator pneumonia
NCT ID NCT03149640
First seen Jan 05, 2026 · Last updated Jun 23, 2026 · Updated 23 times
Summary
This study tested whether giving inhaled amikacin for three days could prevent pneumonia in 850 adults on breathing machines. Patients received either the drug or a placebo starting day 4 of ventilation. The goal was to see if the treatment reduced pneumonia cases up to day 28.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Service de Réanimation
Dijon, 21079, France
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Service de Réanimation
Le Mans, 72037, France
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Service de Réanimation - NHC
Strasbourg, 67091, France
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Service de Réanimation Chirurgicale
Angers, 49933, France
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Service de Réanimation Médicale
Orléans, 45100, France
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Service de Réanimation Médicale
Poitiers, 86021, France
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Service de Réanimation Médicale - CH d'Angoulême
Angoulême, 16959, France
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Service de Réanimation Médicale - CHD Les Oudairies
La Roche-sur-Yon, 85025, France
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Service de Réanimation Médicale - CHU La Milétrie
Poitiers, 86021, France
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Service de Réanimation Médicale - CHU Pontchaillou
Rennes, 35033, France
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Service de Réanimation Médicale - CHU Rouen
Rouen, 76031, France
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Service de Réanimation Médicale - Hôpital Charles Nicolle
Rouen, 76031, France
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Service de Réanimation Médicale - Hôpital La Croix-Rousse
Lyon, 69317, France
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Service de Réanimation Médicale - Hôpital Louis Mourier
Colombes, 92700, France
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Service de Réanimation Médicale - Hôpital Pitié Salpêtrière
Paris, 75013, France
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Service de Réanimation Médicale - Hôpital de Hautepierre
Strasbourg, 67098, France
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Service de Réanimation Polyvalente
Argenteuil, France
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Service de Réanimation médicale, Hôpital Trousseau
Tours, 37044, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
inhaled amikacin
What this could lead to
If it works, this could offer a simple way to prevent pneumonia in patients on breathing machines, reducing illness and antibiotic use.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all ICU settings. Inhaled antibiotics can cause airway irritation or resistance.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.