Could a simple gas reduce lung damage in ventilator patients?
NCT ID NCT05559970
First seen May 08, 2026 · Last updated Jun 21, 2026 · Updated 5 times
Summary
This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and only measured short-term changes, so more research is needed.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, 10700, Thailand
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
isoflurane
What this could lead to
If it works, this could point toward a better sedation method that reduces lung injury and improves recovery for ICU patients on ventilators.
What could go wrong
This is a very small pilot study (40 patients) that only looks at short-term changes in lung mechanics, not long-term outcomes. The results may not apply to all ICU patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.