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Military study aims to find the best flu shot

NCT ID NCT03734237

Vaccine Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large study enrolled over 15,000 U.S. military members to compare three types of licensed flu vaccines: egg-based, recombinant, and cell-culture-based. Participants were randomly assigned to one of the three vaccines over four flu seasons. The main goal is to see which vaccine best prevents lab-confirmed flu. Results could help guide flu shot choices in the military.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
influenza vaccines (egg-based, recombinant, and cell-culture-based)
What this could lead to
If successful, this study could show which flu vaccine type is most effective for military personnel, helping to reduce flu illness in this population.
What could go wrong
This is a pragmatic trial, not a placebo-controlled one, so results may be influenced by real-world factors. Also, flu viruses change each year, so effectiveness may vary across seasons.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

15,448 people

The number who actually took part.

Started

Nov 2018

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Eligible for care in Department of Defense medical facilities (Defense Enrollment Eligibility Reporting System eligible) 2. ≥18 years of age. 3. At a participating Military Treatment Facility site for the purpose of receiving a seasonal (2018-2019, 2019-2020,2020-2021, 2021-2022) influenza vaccination. 4. Able to speak English and able to provide informed consent 5. Able to receive and respond to texts and/or emails, or a military recruit Exclusion Criteria: 1. Adults intending to receive or who have received the current seasons FluMist Vaccine (LAIV) 2. Adults who have already received a flu vaccine within the current season 3. Individual who cannot receive a flu vaccine or standard dosing due to another medical condition 4. Allergic to gentamicin, polymyxin and/or neomycin 5. Individuals who fail to meet the inclusion criteria

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Influenza Influenza -like illness Influenza vaccines

Contacts and locations

Locations

  • Brooke Army Medical Center

    Fort Sam Houston, Texas, 78234, United States

  • Lackland Airforce Base

    San Antonio, Texas, 78243, United States

  • Madigan Army Medical Center

    Tacoma, Washington, 98431, United States

  • Naval Medical Center Portsmouth

    Portsmouth, Virginia, 23704, United States

  • Naval Medical Center San Diego

    San Diego, California, 34800, United States

  • USU

    Bethesda, Maryland, 20307, United States

  • United States Naval Academy

    Annapolis, Maryland, 21402, United States

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20814, United States

  • Womack Army Medical Center

    Fort Bragg, North Carolina, 28310, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.