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Surgery brain study may reveal early Alzheimer's clues

NCT ID NCT05991830

Knowledge-focused Sponsor: University of Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study measured inflammation markers and brain activity in 20 older adults during elective surgery. Researchers wanted to see if these factors could be early signs of Alzheimer's disease. The study is complete and aimed at understanding, not treating, the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify early signs of Alzheimer's risk in older adults undergoing surgery.
What could go wrong
This is a small, completed observational study with only 20 participants. It does not test a treatment, so results may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

20 people

The number who actually took part.

Started

Aug 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Cohort of patients \> 60 years of age who will undergo elective surgery under general anesthesia

Ages

60 to 80 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults over 60 years of age undergoing elective surgery 2. Able to understand and sign an informed consent form Exclusion Criteria: 1. Diagnosis of other neurological pathologies 2. No active acute or chronic decompensated diseases 3. No severe psychiatric illnesses 4. Propofol allergy

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Conditions

The condition(s) this trial relates to.

Cognition Disorders cognitive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognition disorder

Contacts and locations

Locations

  • Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile

    Santiago, RM, 7690306, Chile

  • Hospital Clinico de la Universidad de Chile

    Santiago, RM, 7690306, Chile

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