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Revolutionary ICU trial aims to save lives by constantly learning from every patient

NCT ID NCT06667999

Knowledge-focused Sponsor: Anders Perner Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial aims to improve care for critically ill patients in intensive care units (ICUs) by testing many treatments at once in a flexible way. It will involve up to 10,000 adults admitted to the ICU. The goal is to quickly find which treatments work best and stop those that are harmful or wasteful, directly helping patients and easing the strain on healthcare systems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The general eligibility criteria below apply to INCEPT as a whole and thus to all domains. Domains may impose domain-specific eligibility criteria that restrict the population eligible for that domain further, but domains are not allowed to broaden the general eligibility criteria. Domain-specific eligibility criteria always apply to all arms in a domain. PLATFORM INCLUSION CRITERIA: * Adult patient (≥18 years old) acutely admitted to the ICU. This includes ICU admissions after emergency surgery, unplanned ICU admissions after elective surgery, and prolonged ICU admissions due to complications after elective surgery (i.e., admissions occurring or being prolonged due to an unexpected, worsened condition, but excluding planned ICU admissions after elective surgery without clinical deterioration). * Eligible for at least one active domain. PLATFORM EXCLUSION CRITERIA: * Informed consent following inclusion expected to be unobtainable (e.g., known previous objections to participation). * Patient is under coercive measures (e.g., ongoing involuntary hospital stay or under the jurisdiction of correctional authorities). Patients who have previously been included in INCEPT may only be included again during new ICU admissions but may only be randomised to domains in which they have not previously been randomised. DOMAIN-SPECIFIC ELIGIBLE CRITERIA: Each domain may have additional eligibility criteria. Refer to the study website for more information (www.incept.dk).

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Intensive care patients Intensive care unit patients

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    21 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Anaesthesia, Hospital Sønderjylland

    NOT_YET_RECRUITING

    Aabenraa, 6200, Denmark

  • Anaesthesiology and Intensive Care, Amager and Hvidovre Hospital

    RECRUITING

    Hvidovre, 2650, Denmark

  • Anesthesiology (ICU), Zealand University Hospital, Nykøbing Falster

    NOT_YET_RECRUITING

    Nykøbing Falster, 4800, Denmark

  • Department of Anaesthesia and Intensive Care Medicine, Copenhagen University Hospital - North Zealand

    RECRUITING

    Hillerød, 3400, Denmark

  • Department of Anaesthesia and Intensive Care, Aalborg University Hospital

    RECRUITING

    Aalborg, 9000, Denmark

  • Department of Anaesthesiology and Intensive Care, Gødstrup Hospital

    RECRUITING

    Herning, 7400, Denmark

  • Department of Anaesthesiology and Intensive Care, Regional Hospital Viborg

    RECRUITING

    Viborg, 8800, Denmark

  • Department of Anesthesia and intensive care medicine, Kolding Hospital

    RECRUITING

    Kolding, 6000, Denmark

  • Department of Anesthesia, Zealand University Hospital

    RECRUITING

    Køge, 4600, Denmark

  • Department of Anesthesiology and Intensive Care, Copenhagen University Hospital Herlev

    NOT_YET_RECRUITING

    Herlev, 2730, Denmark

  • Department of Anesthesiology and Intensive Care, Odense University Hospital

    RECRUITING

    Odense, 5000, Denmark

  • Department of Cardiothoracic Anaesthesia and Intensive care, Copenhagen Universisty Hospital - Rigshospitalet

    NOT_YET_RECRUITING

    Copenhagen, 2100, Denmark

  • Department of Intensive Care Nord , Aarhus University Hospital

    RECRUITING

    Aarhus, 8200, Denmark

  • Department of Intensive Care Øst, Aarhus University Hospital

    RECRUITING

    Aarhus, 8200, Denmark

  • Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

  • Department of anesthesiology and intensive care, Bispebjerg-Frederiksberg Hospital

    RECRUITING

    Copenhagen, 2400, Denmark

  • Department. of Anesthesiology and Intensive Care Medicine

    RECRUITING

    Svendborg, 5700, Denmark

  • Esbjerg Hospital

    NOT_YET_RECRUITING

    Esbjerg, 6700, Denmark

  • Intensive care, Slagelse Hospital

    RECRUITING

    Slagelse, 4200, Denmark

  • Neuroanaesthesiology, Copenhagen University Hospital - Rigshospitalet

    NOT_YET_RECRUITING

    Copenhagen, 2100, Denmark

  • Operation og Intensiv, Regional Hospital Randers

    RECRUITING

    Randers, 8930, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.