Heart pump combo tested for shock recovery – trial cut short

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cardiogenic shock: Including refractory to conventional therapy, including systolic blood pressure \< 90mm Hg, Cardiac Index \< 1.8 or a cardiac index \< 2.0 on moderate to high doses of inotropes and vasopressors for greater than 30 mins, or systemic signs of tissue hypoxia. * Post-acute myocardial infarction cardiogenic shock: excluding mechanical complications requiring surgical intervention after extracorpeal membrane oxygenator (ECMO) such as post-ischaemic ventricular septal defect (VSD). * Drug overdose-induced cardiogenic shock. * Early graft failure: post orthotropic heart transplantation cardiogenic shock, excluding immediate intra-operative failure. * Acute on chronic cardiomyopathy with progressive shock and decompensation unresponsive to medical therapies. Exclusion Criteria: * Recent Significant Pulmonary Embolus * Moderate to severe aortic valve insufficiency (AI) * Ongoing significant sepsis * Severe pulmonary hypertension \& shock * Hypothermia * Post-cardiotomy cardiogenic shock * Continuous cardiopulmonary resuscitation (CPR) \>20-30 minutes, except if neurological status is satisfactory * Transfer from outside hospital on VA ECMO or with history of CPR * Listed for cardiopulmonary transplantation or being evaluated for cardiopulmonary transplantation or permanent mechanical circulatory support * Known or suspected chronic heart failure with echocardiogram documenting left ventricular diastolic diameter \>6.5cm * Known or suspected chronic heart failure with echocardiogram documenting left ventricular ejection fraction \< 25% * Mechanical aortic valve replacement * Presence of left ventricular thrombus * Pre-existing Impella 2.5, CP, 3.5 or 5.0 * Cardiogenic shock due to primary respiratory failure * Mechanical complications requiring surgical intervention after ECMO such as post-ischaemic VSD. * Severe liver failure * Active malignancy * Acute aortic dissection * Intracranial hemorrhage * Neurological injury including recent cerebrovascular accident or suspected severe neurologic injury