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Can a quick heart scan save sepsis patients from organ failure?

NCT ID NCT04580888

Knowledge-focused Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether doing an early heart ultrasound (echocardiography) in the emergency department helps doctors manage sepsis or septic shock better. 312 adults with sepsis were randomly assigned to either get the ultrasound plus a treatment guide, or standard care. The goal was to see if the ultrasound approach reduced organ failure over 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
early transthoracic echocardiography (a heart ultrasound procedure)
What this could lead to
If successful, this could show that using early heart ultrasound helps doctors make better treatment decisions for sepsis patients, potentially reducing organ damage.
What could go wrong
This is a completed study, but its findings may not change standard practice if the intervention did not significantly improve outcomes. The results are specific to emergency department settings and may not apply elsewhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

312 people

The number who actually took part.

Started

Jul 2021

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients admitted to the ED * Age ≥ 18 years and affiliation to Social Security * With sepsis (Sepsis-3 definition): Clinically suspected or documented acute infection AND a quick score Sequential Organ Failure Assessment (qSOFA) ≥ 2 points with: * Systolic blood pressure ≤ 100 mmHg (1 point) requiring fluid loading * AND encephalopathy (1 point) OR respiratory rate ≥ 22 cpm (1 point) AND a systolic blood pressure ≤ 100 mmHg after 500 mL of crystalloid vascular filling - Informed consent Exclusion Criteria: * Decision to limit care or moribund status * Pregnancy or breast feeding * Subject under juridical protection.

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Conditions

The condition(s) this trial relates to.

Emergencies infectious disease with sepsis multiple organ dysfunction syndrome Sepsis Toxemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Echocardiography Emergencies Organ dysfunction syndrome sepsis Sepsis

Contacts and locations

Locations

  • CH d'Albi

    Albi, 81000, France

  • CH d'Eaubonne - Montmorency

    Eaubonne, 95600, France

  • Grenoble university hospital

    La Tronche, 38700, France

  • Hospices civils de Lyon

    Lyon, 69003, France

  • La réunion university hospital

    Saint-Pierre, 97410, France

  • Limgoes university hospital

    Limoges, 87042, France

  • Nantes university hospital

    Nantes, 44093, France

  • Nice university hospital

    Nice, 06600, France

  • Poitiers university hospital

    Poitiers, 86000, France

  • Toulouse university hospital

    Toulouse, 31059, France

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