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Could a protein on blood cancer cells lead to a new treatment?

NCT ID NCT07455500

Knowledge-focused Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at a protein called IL-1RAP found on the surface of certain blood cancer cells in myelodysplastic syndromes (MDS). Researchers want to see if this protein can be targeted by a special immune therapy called CAR-T cells. They will collect bone marrow and blood samples from 120 people with MDS to study the protein and test the therapy in the lab and in mice. This is a first step toward possibly developing a new treatment for high-risk MDS.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
IL-1RAP-targeted CAR-T cells (investigational immunotherapy)
What this could lead to
If successful, this could point toward a new immunotherapy treatment for high-risk myelodysplastic syndromes, a condition with few options beyond stem cell transplant.
What could go wrong
This is a very early, lab-based study using patient samples and mice. It does not test the therapy in humans yet, so it may not work in actual patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jan 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient with Myelodysplastic Syndrome (MDS) * Low-risk MDS according to the IPSS-M (20). * MDS confirmed by bone marrow cytology with a blast percentage between 5% and 19% and/or associated with cytogenetic abnormalities or gene mutations indicating poor prognosis. * High-risk MDS according to the IPSS-M * At diagnosis or in cases of relapse/refractoriness to hypomethylating agents or to allogeneic hematopoietic stem cell transplantation. Exclusion Criteria: * Patient not diagnosed with MDS or patient diagnosed with acute myeloid leukemia. * Patient with an active solid tumor or another active hematologic malignancy requiring treatment. * Patient with a contraindication to performing bone marrow aspiration. * Individuals referred to in Articles L1121-6 to L1121-8 of the French Public Health Code

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Conditions

The condition(s) this trial relates to.

myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myelodysplastic syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.