Iceland launches massive screening study for early cancer detection
NCT ID NCT03327597
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is screening over 80,000 people in Iceland to see if early detection of a condition called MGUS can prevent or improve outcomes for multiple myeloma, a type of blood cancer. Participants are randomly assigned to routine care or closer monitoring. The goal is to compare survival and complications between the groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could show that population-wide screening for MGUS helps catch multiple myeloma earlier, potentially improving survival and reducing treatment complications.
- What could go wrong
- This is an observational screening study, not a treatment trial. It may not prove that screening saves lives, and there is a risk of overdiagnosis or unnecessary anxiety.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80,761 people
The number who actually took part.
- Started
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Sep 2016
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Born 1975 or earlier * With registered address in Iceland on November 1st 2016 Exclusion Criteria: * Prior multiple myeloma * Lymphoproliferative disease * Amyloidosis * M-protein \>30 g/L or involved:uninvolved serum FLC ratio \>100 Individuals with prior history of MGUS will be offered to be randomized into either moderate or intensive clinical follow-up (arms 2 or 3).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Iceland
Reykjavik, Iceland
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Other studies related to the condition(s) this trial covers.
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