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New hope for HIV patients with aggressive lymphoma: targeted drug combo shows promise

NCT ID NCT03220022

First seen Apr 19, 2026 · Last updated May 24, 2026 · Updated 6 times

Summary

This early-stage trial tests a new drug, ibrutinib, combined with standard chemotherapy for people with HIV who have advanced diffuse large B-cell lymphoma. The goal is to find the safest dose and see if the combination can better control the cancer. About 46 participants will be enrolled.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • John H Stroger Jr Hospital of Cook County

    Chicago, Illinois, 60612, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Memorial Hospital West

    Pembroke Pines, Florida, 33028, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Pennsylvania Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Siteman Cancer Center at Washington University

    St Louis, Missouri, 63110, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCSF Medical Center-Parnassus

    San Francisco, California, 94143, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Illinois College of Medicine - Chicago

    Chicago, Illinois, 60612, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • Virginia Mason Medical Center

    Seattle, Washington, 98101, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.