Could a camera in the womb replace surgery for mysterious pregnancies?
NCT ID NCT07469605
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether a thin camera inserted into the uterus (hysteroscopy) can better diagnose pregnancy of unknown location—when an early pregnancy isn't visible on ultrasound—compared to the standard surgical scraping (D&C). Sixty infertility patients with abnormal hormone trends will undergo both procedures, and doctors will compare which method more accurately identifies the pregnancy type. If hysteroscopy works well, it could be done in a clinic, speeding up diagnosis and reducing the need for strong medication.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hysteroscopy
- What this could lead to
- If successful, this technique could provide a faster, more accurate diagnosis of pregnancy of unknown location, reducing unnecessary methotrexate treatment and improving patient experience.
- What could go wrong
- This is a small pilot study with only 60 participants, so results may not apply to all patients. Hysteroscopy may not be more accurate than the current standard D&C.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients 18 years of age and older * Patients undergoing care with (1) positive serum hcg and (2) abnormal hcg trend, as defined by \<50% rise in bHCG over 48h period, repeated across three lab values. * Patients with pregnancy via unassisted conception, conception after ovulation induction and/or intrauterine insemination, and/or embryo transfer * Well established pregnancy dating, either with known LMP, or dating by IUI or embryo transfer Exclusion Criteria: * Patients with known abnormal cavity (history of fibroids, septum, or uterine anomaly) * Patients who are hemodynamically unstable or with an acute abdomen
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Penn Fertility Care
RECRUITINGPhiladelphia, Pennsylvania, 19103, United States