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A tiny molecule may shield sperm DNA from freezing damage

NCT ID NCT04011813

Disease control Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests whether adding hypotaurine, a natural antioxidant, to the media used for sperm preparation and freezing can protect sperm DNA from damage. The study compares sperm samples from 33 participants, processed with or without hypotaurine, through a freeze-thaw cycle. Researchers will measure DNA integrity, chromatin packaging, and other sperm quality indicators to see if hypotaurine offers a protective effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hypotaurine
What this could lead to
If it works, this could lead to better sperm preservation techniques, potentially improving success rates for fertility treatments using frozen sperm.
What could go wrong
This is a small, early-stage trial. The benefits may not be significant, and the results may not apply to all sperm samples or fertility outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

33 people

The number who actually took part.

Started

May 2014

Finished

May 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Men undergoing routine semen analysis at the Center for Reproductive Medicine

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * None Exclusion Criteria: * None

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryopreservation Human spermatozoa parameters Hypotaurine supplementation Spermatozoa DNA alterations

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