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Too much oxygen in ICU linked to higher death risk

NCT ID NCT07549763

Knowledge-focused Sponsor: Trakya University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 260 adults in the intensive care unit (ICU) who needed oxygen therapy. Researchers found that about 60% of patients had too much oxygen in their blood (hyperoxemia). Those with hyperoxemia had longer stays in the ICU and hospital, and a much higher chance of dying (82.5% vs 50.4%). The study suggests that carefully adjusting oxygen levels in critically ill patients is very important.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

260 people

The number who actually took part.

Started

Jun 2021

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study included 260 patients aged 18-85 years who received non-invasive or invasive oxygen therapy for respiratory failure as indicated in the Surgical, Reanimation and Postoperative intensive care units of Trakya University Faculty of Medicine Hospital and who were found to have hyperoxia within the first 24 hours of treatment.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients between the ages of 18-85 * Patients in the intensive care unit receiving non-invasive or invasive oxygen therapy due to respiratory failure * Patients who develop hyperoxia within the first 24 hours of treatment Exclusion Criteria: * Patients who stayed in the intensive care unit for less than 24 hours * Patients suspected of brain death * Patients suspected of being pregnant

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CPAP Hyperoxemia Intensive care unit (ICU) Invasive mechanical ventilation Mortality

Contacts and locations

Locations

  • Trakya Üniversitesi Tip Fakültesi

    Edirne, Merkez, 22100, Turkey (Türkiye)

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