Can pressurized oxygen beat Flesh-Eating bacteria?

NCT ID NCT07170020

Disease control Sponsor: Corewell Health West Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study will test whether adding hyperbaric oxygen therapy to standard care helps people with necrotizing fasciitis, a severe flesh-eating infection. Researchers will compare death rates and complications in 160 adults who receive the treatment versus historical controls. The goal is to see if the oxygen treatment improves survival and reduces the need for repeated surgeries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber)
What this could lead to: If it works, this could provide a proven way to lower death and complication rates from severe flesh-eating infections.
What could go wrong: This trial hasn't started yet and is relatively small. Prior evidence is from case studies, so the benefit is uncertain. Hyperbaric oxygen can cause ear or sinus pain and, rarely, lung injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 18 years old * Patients with documented necrotizing fasciitis or necrotizing soft tissue infection as assessed during initial bedside evaluation, in conjunction with available laboratory values, imaging showing gas in soft tissues consitent with necrotizing infection, or surgical debridement of necrosis of fascia, muscle, and variable levels of soft tissue involvement * Patient or advocate is able to sign consent Exclusion Criteria: * Pediatric patients * Pregnant patients * Patients deemed unlikely to survive or unable to go to surgical debridement

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Conditions

The condition(s) this trial relates to.

fasciitis necrotizing fasciitis necrotizing soft tissue infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Necrotizing fascitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can pressurized oxygen beat Flesh-Eating bacteria?

What the study statuses mean